Drug interactions
Capecitabine + Vandetanib
Severity: Major
Capecitabine and Vandetanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked, dose-related QT prolongation with a boxed warning for torsades de pointes. Capecitabine may add to this effect, so the arrhythmia risk is increased.
What this interaction means in plain words
Capecitabine and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capecitabine belongs to Oncology; Vandetanib belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization, with vandetanib as the dominant QT-prolonging drug.
What to do
Avoid combining where possible, or monitor ECG and electrolytes frequently. Interrupt vandetanib or reduce its dose if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capecitabine and Vandetanib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Capecitabine
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Capecitabine with Vandetanib?
MediHelp rates the interaction as major. Capecitabine and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib causes marked, dose-related QT prolongation with a boxed warning for torsades de pointes. Capecitabine may add to this effect, so the arrhythmia risk is increased.
How serious is the interaction between Capecitabine and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor ECG and electrolytes frequently. Interrupt vandetanib or reduce its dose if QTc becomes markedly prolonged.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
