Drug interactions
Capivasertib + Diltiazem
Severity: Moderate
Capivasertib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase capivasertib exposure through CYP3A4 inhibition, potentially worsening hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of capivasertib by diltiazem.
What to do
Reduce the capivasertib dose per labeling when used with moderate CYP3A inhibitors, and monitor blood glucose and skin and GI toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Diltiazem?
MediHelp rates the interaction as moderate. Capivasertib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase capivasertib exposure through CYP3A4 inhibition, potentially worsening hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose per labeling when used with moderate CYP3A inhibitors, and monitor blood glucose and skin and GI toxicity.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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