Drug interactions
Capivasertib + Dofetilide
Severity: Major
Capivasertib and Dofetilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib may increase dofetilide concentrations by reducing renal secretion. Dofetilide has a narrow therapeutic index, and raised levels can cause QT prolongation and torsades de pointes.
What this interaction means in plain words
Capivasertib and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Dofetilide belongs to Cardiovascular.
Why it happens
Inhibition of renal OCT2/MATE transporters reduces dofetilide tubular secretion.
What to do
Avoid the combination if possible, or use an alternative antiarrhythmic. If it cannot be avoided, monitor QTc and renal function closely and reduce the dofetilide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Capivasertib
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Capivasertib with Dofetilide?
MediHelp rates the interaction as major. Capivasertib and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capivasertib may increase dofetilide concentrations by reducing renal secretion. Dofetilide has a narrow therapeutic index, and raised levels can cause QT prolongation and torsades de pointes.
How serious is the interaction between Capivasertib and Dofetilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use an alternative antiarrhythmic. If it cannot be avoided, monitor QTc and renal function closely and reduce the dofetilide dose.
What other medicines interact with Capivasertib?
MediHelp also lists interactions of Capivasertib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Capivasertib page.
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