Drug interactions
Capivasertib + Efavirenz
Severity: Major
Capivasertib and Efavirenz: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
CYP3A inducers lower capivasertib exposure, and efavirenz may therefore reduce its anticancer efficacy.
What this interaction means in plain words
Capivasertib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing capivasertib metabolism.
What to do
Avoid concomitant use and select a non-inducing antiretroviral. If it cannot be avoided, monitor tumor response closely with the oncology team.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Efavirenz?
MediHelp rates the interaction as major. Capivasertib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. CYP3A inducers lower capivasertib exposure, and efavirenz may therefore reduce its anticancer efficacy.
How serious is the interaction between Capivasertib and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a non-inducing antiretroviral. If it cannot be avoided, monitor tumor response closely with the oncology team.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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