Drug interactions
Capivasertib + Fentanyl
Severity: Major
Capivasertib and Fentanyl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is a CYP3A inhibitor and may raise fentanyl concentrations. This may intensify sedation and respiratory depression.
What this interaction means in plain words
Capivasertib and Fentanyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fentanyl.
What to do
Monitor for respiratory depression and sedation and reduce the fentanyl dose if needed. Take extra care when starting capivasertib in patients on stable opioid doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capivasertib and Fentanyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Capivasertib
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Capivasertib with Fentanyl?
MediHelp rates the interaction as major. Capivasertib and Fentanyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capivasertib is a CYP3A inhibitor and may raise fentanyl concentrations. This may intensify sedation and respiratory depression.
How serious is the interaction between Capivasertib and Fentanyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and reduce the fentanyl dose if needed. Take extra care when starting capivasertib in patients on stable opioid doses.
What other medicines interact with Capivasertib?
MediHelp also lists interactions of Capivasertib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Capivasertib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
