Drug interactions
Capivasertib + Isoniazid
Severity: Moderate
Capivasertib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP3A4, which is the main metabolic pathway of capivasertib, so exposure may increase. This could worsen hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by isoniazid reduces capivasertib metabolism.
What to do
Monitor blood glucose and for diarrhea and rash; reduce the capivasertib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Isoniazid?
MediHelp rates the interaction as moderate. Capivasertib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP3A4, which is the main metabolic pathway of capivasertib, so exposure may increase. This could worsen hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for diarrhea and rash; reduce the capivasertib dose if adverse effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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