Drug interactions
Capivasertib + Metformin
Severity: Moderate
Capivasertib and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib inhibits renal transporters involved in metformin elimination, increasing metformin exposure. This raises the risk of metformin adverse effects, including lactic acidosis, especially if renal function declines.
What this interaction means in plain words
Capivasertib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2 and MATE transporters reduces renal tubular secretion of metformin.
What to do
Monitor serum creatinine and renal function regularly, particularly in the first weeks, and watch for gastrointestinal effects and lactic acidosis. Reduce the metformin dose in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capivasertib
Other interactions of Metformin
Frequently asked questions
Can I take Capivasertib with Metformin?
MediHelp rates the interaction as moderate. Capivasertib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib inhibits renal transporters involved in metformin elimination, increasing metformin exposure. This raises the risk of metformin adverse effects, including lactic acidosis, especially if renal function declines.
How serious is the interaction between Capivasertib and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and renal function regularly, particularly in the first weeks, and watch for gastrointestinal effects and lactic acidosis. Reduce the metformin dose in patients with reduced renal function.
What other medicines interact with Capivasertib?
MediHelp also lists interactions of Capivasertib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Capivasertib page.
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