Drug interactions
Capivasertib + Metronidazole
Severity: Moderate
Capivasertib and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may modestly raise capivasertib levels by inhibiting CYP3A4. Higher exposure could worsen hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
CYP3A4 inhibition by metronidazole may reduce capivasertib metabolism.
What to do
Monitor blood glucose and for gastrointestinal and skin toxicity. Reduce the capivasertib dose per labeling if a clinically relevant interaction is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Metronidazole?
MediHelp rates the interaction as moderate. Capivasertib and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metronidazole may modestly raise capivasertib levels by inhibiting CYP3A4. Higher exposure could worsen hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for gastrointestinal and skin toxicity. Reduce the capivasertib dose per labeling if a clinically relevant interaction is suspected.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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