Drug interactions
Caplacizumab + Enoxaparin
Severity: Major
Caplacizumab and Enoxaparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caplacizumab impairs von Willebrand factor-mediated platelet adhesion and enoxaparin inhibits coagulation, so together they raise the risk of spontaneous and procedural bleeding. Serious hemorrhage can occur, particularly with invasive procedures or other bleeding risk factors.
What this interaction means in plain words
Caplacizumab and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect from inhibition of platelet adhesion (anti-vWF) and anti-Xa/antithrombin-mediated anticoagulation.
What to do
Use together only when clearly indicated and monitor closely for bleeding signs and hemoglobin. Withhold caplacizumab and review anticoagulant dosing if clinically significant bleeding occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Other interactions of Caplacizumab
Frequently asked questions
Can I take Caplacizumab with Enoxaparin?
MediHelp rates the interaction as major. Caplacizumab and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab impairs von Willebrand factor-mediated platelet adhesion and enoxaparin inhibits coagulation, so together they raise the risk of spontaneous and procedural bleeding. Serious hemorrhage can occur, particularly with invasive procedures or other bleeding risk factors.
How serious is the interaction between Caplacizumab and Enoxaparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly indicated and monitor closely for bleeding signs and hemoglobin. Withhold caplacizumab and review anticoagulant dosing if clinically significant bleeding occurs.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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