Drug interactions
Capreomycin + Succinylcholine
Severity: Major
Capreomycin and Succinylcholine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capreomycin has neuromuscular blocking activity and may potentiate or prolong succinylcholine effects, increasing the risk of prolonged paralysis and respiratory depression.
What this interaction means in plain words
Capreomycin and Succinylcholine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Capreomycin has curare-like neuromuscular blocking action that adds to neuromuscular blockade.
What to do
Avoid if possible; otherwise reduce the neuromuscular blocker dose, monitor with train-of-four and ensure prolonged ventilatory support is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Capreomycin with Succinylcholine?
MediHelp rates the interaction as major. Capreomycin and Succinylcholine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has neuromuscular blocking activity and may potentiate or prolong succinylcholine effects, increasing the risk of prolonged paralysis and respiratory depression.
How serious is the interaction between Capreomycin and Succinylcholine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the neuromuscular blocker dose, monitor with train-of-four and ensure prolonged ventilatory support is available.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Colistimethate sodium. The full list is on the Succinylcholine page.
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