Drug interactions
Capsicum + Captopril-hydrochlorothiazide
Severity: Minor
Capsicum and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capsaicin from capsicum can provoke cough through sensory nerve stimulation, which may worsen the cough already common with ACE inhibitors such as captopril. The effect is mostly a nuisance and is poorly documented.
What this interaction means in plain words
Capsicum and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both agents act on airway sensory nerves; ACE inhibitors raise bradykinin and substance P, and capsaicin releases substance P.
What to do
If cough becomes troublesome, review capsicum intake and consider switching from the ACE inhibitor to an ARB if the cough persists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Capsicum with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Capsicum and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capsaicin from capsicum can provoke cough through sensory nerve stimulation, which may worsen the cough already common with ACE inhibitors such as captopril. The effect is mostly a nuisance and is poorly documented.
How serious is the interaction between Capsicum and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If cough becomes troublesome, review capsicum intake and consider switching from the ACE inhibitor to an ARB if the cough persists.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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