Drug interactions
Capsicum + Enalapril-hydrochlorothiazide
Severity: Minor
Capsicum and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capsaicin-containing products taken orally may aggravate cough, which is a common adverse effect of ACE inhibitors such as enalapril. This could make cough harder to attribute and tolerate.
What this interaction means in plain words
Capsicum and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Both ACE inhibitors and capsaicin act on sensory airway nerves via substance P and bradykinin pathways, with additive cough effects.
What to do
If new or worsening cough occurs, review capsicum use and consider stopping it before changing the ACE inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capsicum and Enalapril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Capsicum with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Capsicum and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Capsaicin-containing products taken orally may aggravate cough, which is a common adverse effect of ACE inhibitors such as enalapril. This could make cough harder to attribute and tolerate.
How serious is the interaction between Capsicum and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If new or worsening cough occurs, review capsicum use and consider stopping it before changing the ACE inhibitor.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
