Drug interactions
Captopril + Carbidopa
Severity: Moderate
Captopril and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa is given with levodopa, and levodopa therapy can cause orthostatic hypotension. Patients on captopril may therefore experience more pronounced blood pressure lowering when dopaminergic therapy is started or increased.
What this interaction means in plain words
Captopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of levodopa-derived dopamine and ACE inhibition.
What to do
Check sitting and standing blood pressure when starting levodopa/carbidopa and reduce the captopril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Captopril with Carbidopa?
MediHelp rates the interaction as moderate. Captopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is given with levodopa, and levodopa therapy can cause orthostatic hypotension. Patients on captopril may therefore experience more pronounced blood pressure lowering when dopaminergic therapy is started or increased.
How serious is the interaction between Captopril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sitting and standing blood pressure when starting levodopa/carbidopa and reduce the captopril dose if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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