Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Carbidopa
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa given with levodopa can cause orthostatic hypotension, which may be additive with antihypertensives. The effect is mainly seen when levodopa therapy is started or increased.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from levodopa-derived dopamine and antihypertensive vasodilation and diuresis.
What to do
Monitor sitting and standing blood pressure when starting or titrating levodopa/carbidopa and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa given with levodopa can cause orthostatic hypotension, which may be additive with antihypertensives. The effect is mainly seen when levodopa therapy is started or increased.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when starting or titrating levodopa/carbidopa and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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