Drug interactions
Captopril + Chlorothiazide
Severity: Moderate
Captopril and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide and captopril are frequently combined for additive blood pressure reduction. In volume-depleted or renally impaired patients, the combination can cause excessive hypotension and deterioration of kidney function.
What this interaction means in plain words
Captopril and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from diuretic-induced volume depletion and renin-angiotensin blockade.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or adjusting either drug. Consider a lower starting dose of captopril in patients on diuretics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Captopril with Chlorothiazide?
MediHelp rates the interaction as moderate. Captopril and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorothiazide and captopril are frequently combined for additive blood pressure reduction. In volume-depleted or renally impaired patients, the combination can cause excessive hypotension and deterioration of kidney function.
How serious is the interaction between Captopril and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or adjusting either drug. Consider a lower starting dose of captopril in patients on diuretics.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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