Drug interactions
Captopril + Diazoxide
Severity: Moderate
Captopril and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide is a direct arteriolar vasodilator, particularly in its parenteral form, and can cause marked hypotension. With captopril the hypotensive effect may be additive. Oral diazoxide for hypoglycemia is associated with fluid retention, which may partly offset this.
What this interaction means in plain words
Captopril and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive vasodilation via potassium channel opening and ACE inhibition.
What to do
Monitor blood pressure closely when starting diazoxide and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Captopril with Diazoxide?
MediHelp rates the interaction as moderate. Captopril and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide is a direct arteriolar vasodilator, particularly in its parenteral form, and can cause marked hypotension. With captopril the hypotensive effect may be additive. Oral diazoxide for hypoglycemia is associated with fluid retention, which may partly offset this.
How serious is the interaction between Captopril and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when starting diazoxide and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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