Drug interactions
Captopril + Diflunisal
Severity: Moderate
Captopril and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can diminish the blood pressure lowering effect of captopril and may reduce renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Captopril and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of cyclooxygenase reduces vasodilatory renal prostaglandins, opposing ACE inhibition and lowering glomerular filtration.
What to do
Use the lowest effective diflunisal dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Diflunisal?
MediHelp rates the interaction as moderate. Captopril and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can diminish the blood pressure lowering effect of captopril and may reduce renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Captopril and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diflunisal dose for the shortest time and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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