Drug interactions
Captopril + Dutasteride-tamsulosin
Severity: Moderate
Captopril and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamsulosin, an alpha-blocker, and the ACE inhibitor captopril both lower blood pressure. Together they may cause additive hypotension, dizziness or fainting, especially on starting treatment or in older patients.
What this interaction means in plain words
Captopril and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Additive vasodilatory and blood pressure lowering effects of alpha-1 blockade and ACE inhibition.
What to do
Start tamsulosin at the usual low dose and advise slow position changes. Monitor blood pressure and orthostatic symptoms after changes in either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Captopril and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamsulosin, an alpha-blocker, and the ACE inhibitor captopril both lower blood pressure. Together they may cause additive hypotension, dizziness or fainting, especially on starting treatment or in older patients.
How serious is the interaction between Captopril and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tamsulosin at the usual low dose and advise slow position changes. Monitor blood pressure and orthostatic symptoms after changes in either drug.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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