Drug interactions
Captopril + Levodopa
Severity: Moderate
Captopril and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension and may add to the blood pressure-lowering effect of captopril. Symptomatic hypotension or dizziness may occur, particularly when either drug is started or increased.
What this interaction means in plain words
Captopril and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects: levodopa-derived dopamine causes vasodilation and reduced sympathetic tone while captopril blocks angiotensin II formation.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Captopril with Levodopa?
MediHelp rates the interaction as moderate. Captopril and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension and may add to the blood pressure-lowering effect of captopril. Symptomatic hypotension or dizziness may occur, particularly when either drug is started or increased.
How serious is the interaction between Captopril and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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