Drug interactions
Captopril + Linagliptin-metformin
Severity: Moderate
Captopril and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in diabetic patients on glucose-lowering drugs. DPP-4 inhibitors combined with ACE inhibitors may slightly raise the risk of angioedema, and reduced renal function from ACE inhibition can increase metformin accumulation.
What this interaction means in plain words
Captopril and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
ACE inhibitors improve insulin sensitivity and bradykinin accumulation, while DPP-4 inhibition reduces breakdown of substance P and bradykinin-related peptides, raising angioedema risk.
What to do
Monitor blood glucose and renal function, and counsel patients to report lip, face or tongue swelling immediately. Stop the offending drugs if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Captopril and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in diabetic patients on glucose-lowering drugs. DPP-4 inhibitors combined with ACE inhibitors may slightly raise the risk of angioedema, and reduced renal function from ACE inhibition can increase metformin accumulation.
How serious is the interaction between Captopril and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and counsel patients to report lip, face or tongue swelling immediately. Stop the offending drugs if angioedema occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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