Drug interactions
Captopril + Methohexital
Severity: Moderate
Captopril and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital, a barbiturate anesthetic, can cause hypotension through vasodilation and myocardial depression. In patients taking captopril the drop in blood pressure during induction may be greater.
What this interaction means in plain words
Captopril and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Methohexital belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of barbiturate-induced vasodilation and ACE inhibition.
What to do
Monitor blood pressure continuously during induction, ensure adequate volume status, and have vasopressors available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Methohexital
Frequently asked questions
Can I take Captopril with Methohexital?
MediHelp rates the interaction as moderate. Captopril and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital, a barbiturate anesthetic, can cause hypotension through vasodilation and myocardial depression. In patients taking captopril the drop in blood pressure during induction may be greater.
How serious is the interaction between Captopril and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously during induction, ensure adequate volume status, and have vasopressors available.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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