Drug interactions
Captopril + Obinutuzumab
Severity: Moderate
Captopril and Obinutuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab infusions can cause infusion reactions with hypotension, and antihypertensives may add to this effect. Labeling suggests considering withholding antihypertensives before infusion.
What this interaction means in plain words
Captopril and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Obinutuzumab belongs to Oncology.
Why it happens
Additive hypotension from infusion-related reactions and ACE inhibition.
What to do
Consider holding captopril for about 12 hours before and during the infusion if the patient's blood pressure allows. Monitor blood pressure throughout the infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Captopril with Obinutuzumab?
MediHelp rates the interaction as moderate. Captopril and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obinutuzumab infusions can cause infusion reactions with hypotension, and antihypertensives may add to this effect. Labeling suggests considering withholding antihypertensives before infusion.
How serious is the interaction between Captopril and Obinutuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding captopril for about 12 hours before and during the infusion if the patient's blood pressure allows. Monitor blood pressure throughout the infusion.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
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