Drug interactions
Measles mumps and rubella vaccine + Obinutuzumab
Severity: Contraindicated
Measles mumps and rubella vaccine and Obinutuzumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab depletes B cells, blunting vaccine response, and live vaccines carry a risk of disseminated vaccine-strain infection in immunosuppressed patients. Live vaccination during therapy is not recommended.
What this interaction means in plain words
Measles mumps and rubella vaccine and Obinutuzumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Obinutuzumab belongs to Oncology.
Why it happens
B-cell depletion impairs humoral immunity and allows uncontrolled replication of live attenuated virus.
What to do
Do not give live vaccines during obinutuzumab treatment or until B-cell recovery. Complete needed vaccinations at least 4 weeks before starting therapy where possible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Obinutuzumab?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Obinutuzumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Obinutuzumab depletes B cells, blunting vaccine response, and live vaccines carry a risk of disseminated vaccine-strain infection in immunosuppressed patients. Live vaccination during therapy is not recommended.
How serious is the interaction between Measles mumps and rubella vaccine and Obinutuzumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during obinutuzumab treatment or until B-cell recovery. Complete needed vaccinations at least 4 weeks before starting therapy where possible.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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