Drug interactions
Axicabtagene ciloleucel + Obinutuzumab
Severity: Major
Axicabtagene ciloleucel and Obinutuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab depletes B cells and can cause neutropenia and serious infections. Axicabtagene ciloleucel causes B-cell aplasia, cytopenias and infections. Combined use may deepen immunosuppression, and anti-CD20 therapy can also affect the CD19 target cells of the CAR T product.
What this interaction means in plain words
Axicabtagene ciloleucel and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Obinutuzumab belongs to Oncology.
Why it happens
Additive B-cell depletion and immunosuppression.
What to do
Avoid concurrent use and follow the CAR T product's guidance on washout of prior therapy. If given sequentially, monitor for infection and cytopenias and consider immunoglobulin replacement.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Obinutuzumab
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Obinutuzumab?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Obinutuzumab depletes B cells and can cause neutropenia and serious infections. Axicabtagene ciloleucel causes B-cell aplasia, cytopenias and infections. Combined use may deepen immunosuppression, and anti-CD20 therapy can also affect the CD19 target cells of the CAR T product.
How serious is the interaction between Axicabtagene ciloleucel and Obinutuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and follow the CAR T product's guidance on washout of prior therapy. If given sequentially, monitor for infection and cytopenias and consider immunoglobulin replacement.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Obinutuzumab page.
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