Drug interactions
Captopril + Paclitaxel
Severity: Minor
Captopril and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel infusions can cause hypotension, often related to hypersensitivity reactions or the formulation vehicle. Concomitant captopril may contribute to additional blood pressure reduction.
What this interaction means in plain words
Captopril and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Additive hypotensive effects; paclitaxel-related infusion hypotension adds to ACE inhibitor vasodilation.
What to do
Monitor blood pressure during paclitaxel infusions. Consider holding the antihypertensive dose before infusion if baseline pressure is low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Captopril with Paclitaxel?
MediHelp rates the interaction as minor. Captopril and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel infusions can cause hypotension, often related to hypersensitivity reactions or the formulation vehicle. Concomitant captopril may contribute to additional blood pressure reduction.
How serious is the interaction between Captopril and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during paclitaxel infusions. Consider holding the antihypertensive dose before infusion if baseline pressure is low.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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