Drug interactions
Captopril + Riociguat
Severity: Moderate
Captopril and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is a soluble guanylate cyclase stimulator with vasodilating properties, and captopril lowers blood pressure through ACE inhibition. Used together they can produce additive hypotension, including symptomatic episodes at initiation or dose titration.
What this interaction means in plain words
Captopril and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through different vasodilatory pathways.
What to do
Monitor blood pressure and symptoms of hypotension when starting or up-titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Captopril with Riociguat?
MediHelp rates the interaction as moderate. Captopril and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat is a soluble guanylate cyclase stimulator with vasodilating properties, and captopril lowers blood pressure through ACE inhibition. Used together they can produce additive hypotension, including symptomatic episodes at initiation or dose titration.
How serious is the interaction between Captopril and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or up-titrating either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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