Drug interactions
Captopril + Saxagliptin-metformin
Severity: Moderate
Captopril and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as saxagliptin may increase the risk of angioedema with ACE inhibitors. ACE inhibitors can also enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs.
What this interaction means in plain words
Captopril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Both drug classes reduce degradation of bradykinin and substance P, adding to angioedema risk; ACE inhibitors may improve insulin sensitivity.
What to do
Advise patients to seek care for facial or tongue swelling and stop the drugs if it occurs. Monitor glucose when captopril is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Captopril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as saxagliptin may increase the risk of angioedema with ACE inhibitors. ACE inhibitors can also enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs.
How serious is the interaction between Captopril and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to seek care for facial or tongue swelling and stop the drugs if it occurs. Monitor glucose when captopril is started.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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