Drug interactions
Captopril + Sufentanil
Severity: Moderate
Captopril and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil can cause hypotension and bradycardia, especially during anesthesia. Combined with captopril, blood pressure falls may be greater, particularly under anesthesia or with volume depletion.
What this interaction means in plain words
Captopril and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from opioid-induced vasodilation and bradycardia plus ACE inhibition.
What to do
Monitor blood pressure closely perioperatively. Be ready to give fluids or vasopressors, and consider holding the ACE inhibitor before anesthesia per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Captopril with Sufentanil?
MediHelp rates the interaction as moderate. Captopril and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil can cause hypotension and bradycardia, especially during anesthesia. Combined with captopril, blood pressure falls may be greater, particularly under anesthesia or with volume depletion.
How serious is the interaction between Captopril and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely perioperatively. Be ready to give fluids or vasopressors, and consider holding the ACE inhibitor before anesthesia per local protocol.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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