Drug interactions
Baclofen + Sufentanil
Severity: Major
Baclofen and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen and opioids both depress the central nervous system, and sufentanil is a very potent opioid. Together they can cause profound sedation, hypotension and respiratory depression, and intrathecal baclofen adds particular risk in the perioperative setting.
What this interaction means in plain words
Baclofen and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid mu-receptor agonism and baclofen GABA-B agonism.
What to do
Use reduced opioid doses and monitor respiratory rate, oxygen saturation and level of consciousness, with naloxone available. Continuous monitoring is advisable after sufentanil administration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baclofen
Other interactions of Sufentanil
Frequently asked questions
Can I take Baclofen with Sufentanil?
MediHelp rates the interaction as major. Baclofen and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baclofen and opioids both depress the central nervous system, and sufentanil is a very potent opioid. Together they can cause profound sedation, hypotension and respiratory depression, and intrathecal baclofen adds particular risk in the perioperative setting.
How serious is the interaction between Baclofen and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced opioid doses and monitor respiratory rate, oxygen saturation and level of consciousness, with naloxone available. Continuous monitoring is advisable after sufentanil administration.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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