Drug interactions
Asenapine + Sufentanil
Severity: Major
Asenapine and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil and antipsychotics like asenapine both depress the CNS, so combining them may deepen sedation, lower blood pressure and cause respiratory depression.
What this interaction means in plain words
Asenapine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with additive hypotensive effects.
What to do
Use the lowest effective doses and monitor respiratory rate, sedation level and blood pressure, especially in perioperative settings. Have resuscitation and reversal measures available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Sufentanil
Frequently asked questions
Can I take Asenapine with Sufentanil?
MediHelp rates the interaction as major. Asenapine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids such as sufentanil and antipsychotics like asenapine both depress the CNS, so combining them may deepen sedation, lower blood pressure and cause respiratory depression.
How serious is the interaction between Asenapine and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor respiratory rate, sedation level and blood pressure, especially in perioperative settings. Have resuscitation and reversal measures available.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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