Drug interactions
Captopril + Terbinafine
Severity: Minor
Captopril and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril is partly metabolized by CYP2D6 but is mainly eliminated renally as unchanged drug and disulfide conjugates. A meaningful interaction with terbinafine is not expected.
What this interaction means in plain words
Captopril and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Terbinafine belongs to Anti Fungals.
Why it happens
CYP2D6 inhibition by terbinafine may marginally affect a minor metabolic pathway of captopril.
What to do
No adjustment is needed; monitor blood pressure as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Terbinafine?
MediHelp rates the interaction as minor. Captopril and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Captopril is partly metabolized by CYP2D6 but is mainly eliminated renally as unchanged drug and disulfide conjugates. A meaningful interaction with terbinafine is not expected.
How serious is the interaction between Captopril and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor blood pressure as routine.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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