Drug interactions
Captopril + Tolazamide
Severity: Moderate
Captopril and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas such as tolazamide. Hypoglycemia may occur, especially after starting the ACE inhibitor or in patients with renal impairment.
What this interaction means in plain words
Captopril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity and raise bradykinin levels, adding to the sulfonylurea's hypoglycemic action.
What to do
Monitor blood glucose closely during the first weeks of combined therapy. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Captopril with Tolazamide?
MediHelp rates the interaction as moderate. Captopril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas such as tolazamide. Hypoglycemia may occur, especially after starting the ACE inhibitor or in patients with renal impairment.
How serious is the interaction between Captopril and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the first weeks of combined therapy. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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