Drug interactions
Captopril + Vardenafil
Severity: Minor
Captopril and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and may produce additive hypotension, especially at treatment initiation. Symptoms include dizziness and lightheadedness.
What this interaction means in plain words
Captopril and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and ACE inhibition.
What to do
Monitor blood pressure after starting vardenafil and advise patients to rise slowly. Use the lowest effective dose in patients with low baseline pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Vardenafil?
MediHelp rates the interaction as minor. Captopril and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs lower blood pressure and may produce additive hypotension, especially at treatment initiation. Symptoms include dizziness and lightheadedness.
How serious is the interaction between Captopril and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting vardenafil and advise patients to rise slowly. Use the lowest effective dose in patients with low baseline pressure.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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