Drug interactions
Captopril-hydrochlorothiazide + Carvedilol
Severity: Moderate
Captopril-hydrochlorothiazide and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol has alpha-1 blocking activity along with beta-blockade, and combined with captopril-hydrochlorothiazide it gives additive blood pressure lowering. Orthostatic hypotension, dizziness and bradycardia may occur.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects from alpha/beta-blockade, ACE inhibition and diuresis.
What to do
Monitor blood pressure and heart rate when starting or titrating. Reduce doses if symptomatic hypotension occurs and counsel on slow position changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Carvedilol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol has alpha-1 blocking activity along with beta-blockade, and combined with captopril-hydrochlorothiazide it gives additive blood pressure lowering. Orthostatic hypotension, dizziness and bradycardia may occur.
How serious is the interaction between Captopril-hydrochlorothiazide and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating. Reduce doses if symptomatic hypotension occurs and counsel on slow position changes.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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