Drug interactions
Captopril-hydrochlorothiazide + Celiprolol
Severity: Minor
Captopril-hydrochlorothiazide and Celiprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can reduce the oral absorption of celiprolol, which may weaken its effect. Both agents lower blood pressure, so the net clinical result is usually an additive antihypertensive effect with variable celiprolol exposure.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Celiprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Hydrochlorothiazide reduces gastrointestinal absorption of celiprolol, and the antihypertensive effects of the drugs are additive.
What to do
Monitor blood pressure and heart rate when the combination is started or changed. Adjust the celiprolol dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Celiprolol?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Celiprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can reduce the oral absorption of celiprolol, which may weaken its effect. Both agents lower blood pressure, so the net clinical result is usually an additive antihypertensive effect with variable celiprolol exposure.
How serious is the interaction between Captopril-hydrochlorothiazide and Celiprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when the combination is started or changed. Adjust the celiprolol dose according to response.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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