Drug interactions
Captopril-hydrochlorothiazide + Cephalexin
Severity: Minor
Captopril-hydrochlorothiazide and Cephalexin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin and hydrochlorothiazide are both eliminated partly by renal tubular secretion and may compete. Clinically relevant changes in thiazide effect are unlikely.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Cephalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion.
What to do
No specific action is needed; routine monitoring of blood pressure and electrolytes is enough.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Cephalexin?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Cephalexin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalexin and hydrochlorothiazide are both eliminated partly by renal tubular secretion and may compete. Clinically relevant changes in thiazide effect are unlikely.
How serious is the interaction between Captopril-hydrochlorothiazide and Cephalexin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; routine monitoring of blood pressure and electrolytes is enough.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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