Drug interactions
Captopril-hydrochlorothiazide + Choline magnesium trisalicylate
Severity: Moderate
Captopril-hydrochlorothiazide and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so the effect on blood pressure and renal function is probably smaller. Still, high doses may reduce antihypertensive efficacy and affect kidney function when combined with an ACE inhibitor and diuretic.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-mediated reduction of renal prostaglandin synthesis may reduce renal perfusion and antagonize antihypertensive effects.
What to do
Monitor blood pressure and renal function when starting or changing doses, and keep the patient well hydrated; consider acetaminophen as an alternative for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs, so the effect on blood pressure and renal function is probably smaller. Still, high doses may reduce antihypertensive efficacy and affect kidney function when combined with an ACE inhibitor and diuretic.
How serious is the interaction between Captopril-hydrochlorothiazide and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when starting or changing doses, and keep the patient well hydrated; consider acetaminophen as an alternative for analgesia.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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