Drug interactions
Captopril-hydrochlorothiazide + Citalopram
Severity: Moderate
Captopril-hydrochlorothiazide and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and SSRIs can cause hyponatremia, and together the risk is increased, particularly in older adults. Thiazide-induced hypokalemia or hypomagnesemia may also add to citalopram's QT effect.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
Additive hyponatremia via renal sodium loss (thiazide) and SIADH (SSRI).
What to do
Monitor serum sodium, particularly in the first weeks and in the elderly, and check potassium and magnesium. Stop or switch therapy if symptomatic hyponatremia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Citalopram?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and SSRIs can cause hyponatremia, and together the risk is increased, particularly in older adults. Thiazide-induced hypokalemia or hypomagnesemia may also add to citalopram's QT effect.
How serious is the interaction between Captopril-hydrochlorothiazide and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, particularly in the first weeks and in the elderly, and check potassium and magnesium. Stop or switch therapy if symptomatic hyponatremia develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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