Drug interactions
Captopril-hydrochlorothiazide + Conivaptan
Severity: Moderate
Captopril-hydrochlorothiazide and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan produces aquaresis, which may reduce circulating volume and cause hypotension in patients on an ACE inhibitor and a diuretic. Rapid rises in serum sodium are also a concern when diuretics are used together with it.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vasopressin V1a/V2 antagonism causes free water loss and volume depletion, which adds to diuretic and ACE inhibitor effects on blood pressure.
What to do
Monitor blood pressure, volume status and serum sodium frequently during conivaptan infusion. Hold or reduce the antihypertensive and diuretic if hypotension or overly rapid sodium correction occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Conivaptan?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan produces aquaresis, which may reduce circulating volume and cause hypotension in patients on an ACE inhibitor and a diuretic. Rapid rises in serum sodium are also a concern when diuretics are used together with it.
How serious is the interaction between Captopril-hydrochlorothiazide and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status and serum sodium frequently during conivaptan infusion. Hold or reduce the antihypertensive and diuretic if hypotension or overly rapid sodium correction occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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