Drug interactions
Captopril-hydrochlorothiazide + Cosyntropin
Severity: Minor
Captopril-hydrochlorothiazide and Cosyntropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cosyntropin stimulates adrenal steroid release, which may promote potassium loss and fluid retention and add to thiazide-induced electrolyte depletion. With single diagnostic doses the effect is brief and small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Cosyntropin belongs to Musculoskeletal.
Why it happens
Adrenal stimulation increases mineralocorticoid and glucocorticoid output, adding to renal potassium loss.
What to do
No change is usually needed for a single diagnostic dose; check electrolytes if repeated dosing is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Cosyntropin
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Cosyntropin?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Cosyntropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cosyntropin stimulates adrenal steroid release, which may promote potassium loss and fluid retention and add to thiazide-induced electrolyte depletion. With single diagnostic doses the effect is brief and small.
How serious is the interaction between Captopril-hydrochlorothiazide and Cosyntropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed for a single diagnostic dose; check electrolytes if repeated dosing is used.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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