Drug interactions
Captopril-hydrochlorothiazide + Cyclosporine
Severity: Moderate
Captopril-hydrochlorothiazide and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia, hyperuricemia and renal impairment, while thiazides can cause hyponatremia, hyperuricemia and volume depletion. Combined with an ACE inhibitor, the risks of renal dysfunction and hyperkalemia are increased, and gout risk may rise with thiazide use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic, electrolyte and hemodynamic effects of cyclosporine, the ACE inhibitor and the thiazide.
What to do
Monitor serum creatinine, potassium, sodium, uric acid and blood pressure regularly, and adjust doses if renal function or electrolytes deteriorate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Cyclosporine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia, hyperuricemia and renal impairment, while thiazides can cause hyponatremia, hyperuricemia and volume depletion. Combined with an ACE inhibitor, the risks of renal dysfunction and hyperkalemia are increased, and gout risk may rise with thiazide use.
How serious is the interaction between Captopril-hydrochlorothiazide and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium, sodium, uric acid and blood pressure regularly, and adjust doses if renal function or electrolytes deteriorate.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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