Drug interactions
Captopril-hydrochlorothiazide + Dextroamphetamine
Severity: Moderate
Captopril-hydrochlorothiazide and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine raises blood pressure through sympathomimetic effects and can counteract the antihypertensive action of captopril and hydrochlorothiazide. Blood pressure control may deteriorate.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor effect of amphetamine opposes antihypertensive therapy.
What to do
Monitor blood pressure regularly and adjust antihypertensive therapy or stimulant dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dextroamphetamine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine raises blood pressure through sympathomimetic effects and can counteract the antihypertensive action of captopril and hydrochlorothiazide. Blood pressure control may deteriorate.
How serious is the interaction between Captopril-hydrochlorothiazide and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly and adjust antihypertensive therapy or stimulant dose if control is lost.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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