Drug interactions
Captopril-hydrochlorothiazide + Dichlorphenamide
Severity: Moderate
Captopril-hydrochlorothiazide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote renal potassium loss, and together hypokalemia and metabolic acidosis may be more pronounced. Hypokalemia can provoke arrhythmias, particularly if the patient takes digoxin or QT-prolonging drugs.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition and thiazide action.
What to do
Monitor serum potassium and bicarbonate regularly and supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote renal potassium loss, and together hypokalemia and metabolic acidosis may be more pronounced. Hypokalemia can provoke arrhythmias, particularly if the patient takes digoxin or QT-prolonging drugs.
How serious is the interaction between Captopril-hydrochlorothiazide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and supplement potassium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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