Drug interactions
Captopril-hydrochlorothiazide + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Minor
Captopril-hydrochlorothiazide and Elvitegravir / cobicistat / emtricitabine / tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6, but captopril relies mainly on renal elimination, so a meaningful rise in captopril levels is unlikely. Tenofovir is renally cleared and nephrotoxic, and an ACE inhibitor with a diuretic can reduce renal perfusion in volume-depleted patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Elvitegravir / cobicistat / emtricitabine / tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Minor CYP2D6 inhibition by cobicistat; possible additive renal stress from tenofovir, ACE inhibition and diuretic use.
What to do
Monitor renal function and blood pressure, particularly in patients who are volume depleted.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Elvitegravir / cobicistat / emtricitabine / tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat inhibits CYP2D6, but captopril relies mainly on renal elimination, so a meaningful rise in captopril levels is unlikely. Tenofovir is renally cleared and nephrotoxic, and an ACE inhibitor with a diuretic can reduce renal perfusion in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood pressure, particularly in patients who are volume depleted.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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