Drug interactions
Captopril-hydrochlorothiazide + Epinephrine racemic
Severity: Moderate
Captopril-hydrochlorothiazide and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, especially when absorbed systemically, can shift potassium into cells and lower serum potassium. With hydrochlorothiazide, hypokalemia risk is increased, and the pressor effect may oppose antihypertensive therapy.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated cellular potassium uptake adds to thiazide-induced urinary potassium loss.
What to do
Monitor serum potassium and blood pressure when repeated or high-dose epinephrine is used. Replace potassium as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Epinephrine racemic?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine, especially when absorbed systemically, can shift potassium into cells and lower serum potassium. With hydrochlorothiazide, hypokalemia risk is increased, and the pressor effect may oppose antihypertensive therapy.
How serious is the interaction between Captopril-hydrochlorothiazide and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure when repeated or high-dose epinephrine is used. Replace potassium as indicated.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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