Drug interactions
Captopril-hydrochlorothiazide + Epinephrine
Severity: Moderate
Captopril-hydrochlorothiazide and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can cause a transient fall in serum potassium by driving it into cells via beta-2 receptors, which adds to thiazide-induced potassium depletion. Hypokalemia may increase arrhythmia risk during epinephrine use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Beta-2 mediated cellular potassium uptake adds to renal potassium loss from thiazide.
What to do
Monitor serum potassium and ECG when epinephrine is given repeatedly or by infusion, and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Epinephrine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can cause a transient fall in serum potassium by driving it into cells via beta-2 receptors, which adds to thiazide-induced potassium depletion. Hypokalemia may increase arrhythmia risk during epinephrine use.
How serious is the interaction between Captopril-hydrochlorothiazide and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG when epinephrine is given repeatedly or by infusion, and correct hypokalemia.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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