Drug interactions
Captopril-hydrochlorothiazide + Fentanyl intranasal
Severity: Minor
Captopril-hydrochlorothiazide and Fentanyl intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release and blunt the diuretic effect of hydrochlorothiazide. Fentanyl may also add to hypotension, particularly on standing. The effect is generally small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release opposing diuresis, with additive hypotension from opioid vasodilation.
What to do
Monitor blood pressure and fluid status, and adjust the diuretic if effectiveness declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Fentanyl intranasal?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release and blunt the diuretic effect of hydrochlorothiazide. Fentanyl may also add to hypotension, particularly on standing. The effect is generally small.
How serious is the interaction between Captopril-hydrochlorothiazide and Fentanyl intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status, and adjust the diuretic if effectiveness declines.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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