Drug interactions
Captopril-hydrochlorothiazide + Ferric gluconate
Severity: Minor
Captopril-hydrochlorothiazide and Ferric gluconate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors have been associated with a higher chance of hypotensive or hypersensitivity-type reactions to intravenous iron. Reactions such as flushing and low blood pressure are mostly infusion-related and usually resolve after slowing or stopping the infusion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not well established; ACE inhibition may reduce compensation for infusion-related vasodilation and hypotension.
What to do
Give ferric gluconate at the recommended infusion rate and monitor blood pressure and symptoms during and after the infusion. Stop the infusion if hypotension or a reaction occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ferric gluconate?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Ferric gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors have been associated with a higher chance of hypotensive or hypersensitivity-type reactions to intravenous iron. Reactions such as flushing and low blood pressure are mostly infusion-related and usually resolve after slowing or stopping the infusion.
How serious is the interaction between Captopril-hydrochlorothiazide and Ferric gluconate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give ferric gluconate at the recommended infusion rate and monitor blood pressure and symptoms during and after the infusion. Stop the infusion if hypotension or a reaction occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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