Drug interactions
Captopril-hydrochlorothiazide + Ganciclovir
Severity: Minor
Captopril-hydrochlorothiazide and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir is cleared mainly by the kidneys, including tubular secretion. Reduced renal function from diuretic-related volume depletion or ACE inhibitor effects may raise ganciclovir levels and increase hematologic or other toxicity. A direct tubular competition effect with hydrochlorothiazide is theoretical.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ganciclovir belongs to Anti Virals.
Why it happens
Possible reduced renal clearance of ganciclovir through competition for tubular secretion or reduced renal function.
What to do
Monitor renal function and blood counts during ganciclovir therapy, adjusting the dose for creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ganciclovir?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir is cleared mainly by the kidneys, including tubular secretion. Reduced renal function from diuretic-related volume depletion or ACE inhibitor effects may raise ganciclovir levels and increase hematologic or other toxicity. A direct tubular competition effect with hydrochlorothiazide is theoretical.
How serious is the interaction between Captopril-hydrochlorothiazide and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts during ganciclovir therapy, adjusting the dose for creatinine clearance.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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