Drug interactions
Captopril-hydrochlorothiazide + Gold sodium thiomalate
Severity: Moderate
Captopril-hydrochlorothiazide and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these appear more likely in patients taking ACE inhibitors. The reactions are usually not fatal but can be distressing and may lead to stopping treatment.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not fully established; ACE inhibition probably potentiates vasodilatory and kinin-mediated effects of gold.
What to do
Consider an alternative to the ACE inhibitor or alternative DMARD where possible. If combined, observe the patient after each gold injection and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these appear more likely in patients taking ACE inhibitors. The reactions are usually not fatal but can be distressing and may lead to stopping treatment.
How serious is the interaction between Captopril-hydrochlorothiazide and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to the ACE inhibitor or alternative DMARD where possible. If combined, observe the patient after each gold injection and monitor blood pressure.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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